What Happens When the Pancreas Stops Producing Insulin?

Understanding Insulin’s Role

Insulin is a key hormone made by the pancreas that allows your body to use glucose (sugar) from food for energy. Without insulin, glucose builds up in the blood instead of entering cells — leading to high blood sugar (hyperglycemia).

What Happens When Insulin Production Stops?

When the pancreas no longer produces insulin, type 1 diabetes or advanced stages of type 2 diabetes can occur.

Immediate effects include:

  • Persistent high blood sugar
  • Excessive thirst & frequent urination
  • Unexplained weight loss
  • Extreme fatigue

If untreated, it can lead to:

  • Diabetic ketoacidosis (DKA) — a life-threatening condition where the body breaks down fat too quickly, producing toxic acids
  • Organ damage over time (eyes, kidneys, heart, nerves)
Why the Pancreas Stops Making Insulin
  • Autoimmune attack on insulin-producing beta cells (Type 1 Diabetes)
  • Chronic inflammation of the pancreas (pancreatitis)
  • Genetic factors
  • Advanced uncontrolled type 2 diabetes
Managing Life Without Pancreatic Insulin

If your pancreas stops making insulin, external insulin therapy is essential for survival.

Treatment may include:

  • Daily insulin injections or insulin pump therapy
  • Continuous glucose monitoring (CGM)
  • Diet & lifestyle modifications
Expert Care in Hyderabad

If you have unexplained fatigue, extreme thirst, or sudden weight loss, it’s important to check your blood sugar and pancreatic health.

Dr. Pavan K Addala, leading gastroenterologist in Hyderabad, provides advanced evaluation and treatment for pancreatic disorders and diabetes-related complications.